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AOD-9604 accelerates fat loss. The scientific gap There are no high-quality randomized trials demonstrating that semaglutide + AOD-9604 produces better outcomes than semaglutide alone, or that it improves lean mass retention, resting metabolic rate, or long-term weight maintenance

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Adverse events: There were no unexpected safety findings, however, gastrointestinal (GI) side effects were a main cause of treatment discontinuation, which occurred in 16.6% of patients in the semaglutide group vs

Reported findings from experimental models include gastrointestinal effects, altered feeding behavior, and dose-dependent metabolic responses

Dehydration, which can occur with semaglutide, may also mask fat loss on the scale by creating water retention