This activation upregulates both the expression and enzymatic activity of MMP-9, leading to degradation of critical structural components in the basement membrane of the blood-brain barrierparticularly type IV collagenthereby compromising barrier integrity and increasing permeability (105, 106)
Zhou X, Wang Z, Ni Y, Yu Y, Wang G, Chen L
The bidirectional crosstalk between ferroptosis and the immune system profoundly influences treatment outcomes, and this complexity offers valuable insights for clinical translation
IRF1 drives the expression of the transferrin receptor, promotes intracellular Fe2+ accumulation, disrupts iron homeostasis, and induces ferroptosis in cancer cells, while blocking Gln enhances this effect (92)
This is particularly relevant as recent functional studies in Arabidopsis indicate that amino acid metabolism contributes more to plant disease defence than phytoalexins [72,110]