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1 The speed of effect too rapid for transcriptional mechanisms alone suggests that some component of the cytoprotective response is post-translational, likely involving rapid eNOS activation and NO-dependent vasodilation restoring mucosal blood flow

Eumelanin production may be moderately reduced, which can translate into somewhat increased UV sensitivity and a moderate risk of photoaging over time

Elevated intracellular cAMP then drives the following cascade, as characterised in Mel-Ab and B16 melanocyte cell line preparations: MC1R cAMP PKA CREB phosphorylation MITF upregulation tyrosinase expression Picture it this way: MT1 docks at the extracellular binding pocket of MC1R, triggering a conformational shift that couples the receptor to the Gs protein

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McDougle et al., 1994)