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"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity

doi: 10.1136/gut.30.4.430 148 JonderkoKKocaAGoabTJonderkoG

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If this condition is left untreated, gastroparesis could contribute to malnutrition, dehydration, the formation of a bezoar (a solid mass in the stomach), and a host of other health problems

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