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It does this in two ways: by triggering extra insulin, a hormone that helps lower blood sugar levels, and by inhibiting glucagon, a hormone that raises blood sugar levels

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Patients with very low body fat may benefit from using a skin pinch technique, gently gathering skin between thumb and forefinger before injection, to ensure the needle reaches subcutaneous rather than muscle tissue

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doi: 10.1001/jama.257.17.2297 143 HellingerWCSmithTFVan ScoyRESpitzerPGForgacsPEdsonRS

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