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This represents complementary rather than redundant mechanisms

Fluoxetine has a long half-life (46 days), and its active metabolite norfluoxetine has an even longer half-life (up to 16 days), meaning the drug remains in the system longer than many other SSRIs

Building on this foundation, the gradual exploration of intelligent integration with biosensing technologies and controlled drug delivery systems should be pursued to lay the groundwork for personalized, adaptive, closed-loop therapy (57, 67)

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