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"Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial." Lancet , 398(10300), 583-598

Licensed alternatives for weight management include orlistat, semaglutide (Wegovy), and in some cases liraglutide (Saxenda) or naltrexone/bupropion (Mysimba)

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Since GLP-1s slow digestion, large portions can cause severe discomfort, nausea, and even vomiting

However, because the program may include fewer touchpoints or opportunities for follow-up, some users may prefer a model that offers closer clinical oversight