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One case report documented sexual dysfunction in a woman on tirzepatide that resolved upon discontinuation

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It works through two hormone pathways known as GLP-1 and GIP

Its unique effectiveness comes from its dual mechanism: it acts on both the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptors

Metabolic Pathways and Half-Life Tirzepatide is primarily degraded by proteolytic enzymes and exhibits a half-life of approximately five days, enabling once-weekly dosing