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It is little wonder, then, that the development of bioidentical hormones has been a significant advance in the field of hormone replacement therapy, and has made a positive change in countless lives worldwide

On the contrary, MC4R agonist, setmelanotide, was approved for the rare MC4R-deficiency, BardetBiedl syndrome (BBS), with severe obesity in childhood [10, 23]

Unlike the pharmacological agents discussed, it is not likely that these dialysis treatment modifications would be undertaken for the primary purpose of enhancing ESA responsiveness, and they therefore were not considered by the Anemia Work Group for inclusion in Guidelines or CPRs addressing ESA adjuvants

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