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In vivo pharmacodynamic profiling of doripenem against Pseudomonas aeruginosa by simulating human exposures

Treatment was generally well tolerated and safe

Interestingly, the stability of extramitochondrial Fe-S proteins was more varied in response to cystine starvation, with some proteins displaying reduced expression within 20 h of starvation, while the expression of others was unchanged (Supplementary Fig

Here is the fundamental equation