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Oxidative stress induces the dissociation of the NRF2-Keap1 complex When cells undergo oxidative stress, ionizing radiation, or chemical stimulation, it may lead to the generation of reactive oxygen species (ROS) or reactive oxygen free radicals within the cells, triggering an oxidative stress response

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Likewise, a balanced ROS production and ROS-dependent signaling seem to be favorable for normal growth behavior and cellular differentiation