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Clinical trials: Conducted in three rigorous phases, often managed by Contract Research Organisations (CROs) Phase 1: Tests the drug in a small group (20100) of healthy volunteers to check basic safety and dosages Phase 2: Administered to a larger group (100300) of patients to test efficacy and potential side effects

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10.1016/j.kint.2022.01.029 193 XuX.ZhengN.ChenZ.HuangW.LiangT.KuangH