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The trade-off is slightly lower effectiveness and strict daily dosing requirements

Constipation may persist longer than nausea, sometimes extending into week three or four before resolving with increased fiber, water intake, and gentle movement

Common Side Effects Nausea (typically improves after 2-4 weeks) Diarrhea or constipation Decreased appetite (this is the goal) Mild stomach discomfort Fatigue during dose increases When to Call Your Doctor Severe or persistent nausea/vomiting Signs of pancreatitis (severe abdominal pain) Vision changes Rapid heartbeat Signs of allergic reaction Is Semaglutide Right for You

Evaluation of human health risks 1.2.2