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Conclusions These exploratory subgroup analyses support the results of the primary analyses of the PIONEER trials and suggest that oral semaglutide can be used across a broad range of patients with T2D in combination with other commonly used glucose-lowering background medications

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Rovamo LM, Salmenpera L, Arjomaa P, et al

The end products of purine metabolism, uric acid, a potent antioxidant, have been reported to be found in decreased levels in MDD 71,72,73 , while lower cerebro-spinal fluid (CSF) levels of hypoxanthine and xanthine, the two metabolites preceding uric acid, have previously been linked with depression 74