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Tier 3: Renal and Liver Function Any exogenous compound requires organ safety monitoring

During a 17-week off-treatment follow-up period, people who had stopped using tirzepatide began to regain weight, Lilly said in a news release, and there was some increase in the progression to type 2 diabetes. The most frequently reported adverse events were typically gastrointestinal-related and generally mild to moderate in severity, Lilly said

Current pharmaceutical design , 20 (7), 1126-35

never exceed 2 mg per day to avoid serious adverse effects [4]