These local hepatic alterationswhen coupled with systemic inflammation, dysregulated adipokines (e.g., leptin, adiponectin), and circulating profibrotic cytokines (e.g., TGF-, IL-13)amplify fibrotic signaling across distant organs (123, 129)
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Confocal microscopy showed that control oocytes had higher red/green fluorescence ratios, indicating healthy mitochondria, while aged oocytes had lower ratios
( B ) A similar pattern was observed for male transgenic mice treated with intranasal GHK-Cu compared to mice receiving intranasal saline at weeks 4 and 8