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While the peptide demonstrates neuroprotective effects in animal models of ischemia and Parkinsons disease (protecting dopaminergic neurons), no human cognitive data exists

Together these modifications reduce IGFBP binding affinity by approximately 1,000-fold compared to native IGF-1 while preserving IGF-1 receptor (IGF1R) binding

2 4 From a regulatory standpoint, GHK-Cu sits firmly in the cosmetic and research categories, not the pharmaceutical one

Slower progression with survival up to 11 years of age has been observed [126,127,130] , and, in one patient, there was no apparent cognitive impairment at 10 years of age [130]

(accepted)