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Research indicates it specifically activates the VEGFR2/Akt-eNOS signaling pathway, which is a central cascade for its angiogenic and tissue-protective effects

(2) Small molecules and drug inducers targeting lipid metabolism: such as the anti-cancer drug sorafenib, and inhibitors of cardiolipin oxidation like XJB-5131 and JP4039

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Further, it suggests that the inflammatory response is also independent of plaque burden