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Pigmented lesions of the nail unit: Clinical and histopathologic features

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The authors note that this relationships has been "validated across multiple disease models, including synovial macrophages in OA, bone marrow precursor cells in OP, and muscle cells in SP." Additionally, the cellular mechanisms serve an antioxidant purpose via PGC-1 activation and Nrf2 nuclear translocation, GLP-1 upregulates HO-1 and NQO1 while reducing NADPH oxidase activity and ROS generation

45 It should be noted that in this context, SipTilSend and similar limited fasting regimens may not be appropriate for patients on GLP-1 RAs and GLP-1/GIPRA therapy

This happened at much higher non-physiologically relevant concentrations than that stimulated by glucagon previously demonstrated by Samols group (Samols, Marri, Marks, 1966)