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Stage 4: In this advanced stage, the large amounts of lipedema fat put so much pressure on the lymphatic system that lymphedema develops too (this is called lipo-lymphedema)

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A landmark clinical trial published in the Journal of Clinical Endocrinology and Metabolism demonstrating that Ipamorelin produces selective GH release without significant cortisol or prolactin elevation, establishing its safety profile for use in women with hormonally sensitive physiological backgrounds is the foundational study that shaped how the peptide is used today in supervised clinical settings