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It doesn't make me physically ill at all, my brain just says, "Nope, you're done." I can't even explain it because I want to drink but I'm just completely done after one or two

Additionally, tirzepatide acts in the brain to suppress the hormone responsible for hunger, all without causing stimulant-like side effects associated with other appetite suppressants

10.1038/35041687 81 FranceschiC.BonafM.ValensinS.OlivieriF.De LucaM.OttavianiE.et al (2000)

A 2018 randomized controlled trial published in the European Journal of Clinical Nutrition tested this exact regimen in 48 participants consuming five standard drinks over four hours

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