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30, coming in over Pfizers initial $4.9 billion

Gastroenterology 144 , 580590.e7 (2013)

Unlike small-molecule drugs that tolerate moderate temperature variation, peptides rely on precise three-dimensional folding to interact with cellular receptors

Acute Kidney Injury: Gastrointestinal side effects of Zepbound like diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration), which may cause kidney problems if dehydration is severe

Another significant class of drugs consists of camptothecin analogs such as irinotecan, which are derived from the plant Camptotheca acuminata and function as topoisomerase I inhibitors