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At another level, GLP-1RAs also improve systemic insulin sensitivity to lower arterial hypertension in T2DM by decreasing the concentration of angiotensin II (Ang II) [41, 42]

Thirty-four reported adverse effects, including hypersensitivity, injection-site reactions, pruritus, urticaria, angioedema, and immune-mediated conditions like bullous pemphigoid

They are primarily used to manage type 2 diabetes and obesity by enhancing insulin secretion and promoting weight loss

In August 2025, SC Wegovy became the first GLP-1 to be approved for metabolic dysfunction-associated steatohepatitis (MASH)

Additionally, the activation of GIP may amplify the weight loss and insulin secretion effects of GLP1 activation in the central nervous system and pancreas, respectively