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Understanding the established adverse effect profile of semaglutide provides essential context when evaluating new or unexpected symptoms during treatment, including musculoskeletal complaints such as lower back pain

At the end of the trial, 73% of adolescents in the semaglutide group had a reduction in body weight of 5% or greater compared with 18% of those in the placebo group

doi:10.1007/s40262-017-0531-7 156

According to FDA labeling, the development of anti-semaglutide antibodies is infrequent and has not been observed to meaningfully impact the efficacy or pharmacokinetics of the medication in clinical trials

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