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Severe Adverse Events: Severe treatment-emergent adverse events (TEAEs) occurred in 10.1% of the triplet therapy group, compared to 2% in the semaglutide-only group

According to UK product information, the key requirement is that Rybelsus should be taken on an empty stomach with up to 120ml of water, followed by at least 30 minutes before consuming any food, beverages (other than water), or other oral medications (including levothyroxine)