doi:10.1002/mc.20741, PMID: 21319226 Yue P, Zhou Z, Khuri FR, Sun SY (2006) Depletion of intracellular glutathione contributes to JNK-mediated death receptor 5 upregulation and apoptosis induction by the novel synthetic triterpenoid methyl-2-cyano-3, 12-dioxooleana-1, 9-dien-28-oate (CDDO-Me)
We address this by focusing on bioavailabilitythe measure of how much of a substance actually enters your circulation and is able to have an active effect
Nabeno M, Akahoshi F, Kishida H, Miyaguchi I, Tanaka Y, Ishii S, et al
The trial-and-community standard is baseline IGF-1 plus a 4-week recheck and 8-12 week metabolic panel that's how published research designs measured efficacy, and it's what community sources commonly treat as the minimum monitoring set
2001 Sep;131(9 Suppl):2515S-22S