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For further studies, we utilised Gpx4 flox/wt ;Villin-Cre +/ ( Gpx4 +/IEC ) mice 27,28 , which specifically deleted one Gpx4 allele in the intestinal epithelium and resulted in a ~50% reduction of mRNA and protein levels in small and large intestinal IECs (Supplementary Fig

Medically reviewed by Shari Forschen, NP, MA This article was medically reviewed by Shari Forschen, NP, MA

Moreover, elevated viscosity suppresses membrane ruffling, allowing the cell membrane to stay adjacent to the substrate, thus increasing integrin-substrate engagement [208]

Estrogen biosynthesis and signaling pathways are locally activated during physiological wound healing, processes that are inhibited in elderly estrogen-deprived skin

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