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Signs of deficiency may include: Megaloblastic anemiaa condition of larger than normal red blood cells and a smaller than normal amount

The preservative allows opened vials to remain microbially stable for up to 28 days at refrigerated storage

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The desensitisation procedure should be started by the 1/1001/1000 solutions of the drug target or the 1/101/1000 solutions of positive intradermal test dose and in increasing doses by doubling with 3090min intervals until the therapeutic dose is achieved.5 Desensitisation must be carried out in a hospital setting by experienced personnel with adequate resuscitation equipment readily available

The purpose of this treatment is to eliminate matrix constituents that could interfere with the detection process or damage analytical equipment, and to enrich the analyte in the sample so that it is readily available for detection [3], [2]