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Serum leptin levels in women with systemic lupus erythematosus

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10.1007/s11356-020-08947-2 161 WangY.LiN.YangJ.-J.ZhaoD.-M.ChenB.ZhangG.-Q.et al (2020)

The N-terminal methionine oxidizes, creating methionine sulfoxide that alters binding kinetics

"While further research is needed, liraglutide may work through various mechanisms, such as reducing inflammation in the brain, lowering insulin resistance and the toxic effects of Alzheimer's biomarkers amyloid-beta and tau, and improving how the brain's nerve cells communicate." One thing liraglutide didn't appear to do for the patients in this trial was meaningfully improve their brain's glucose metabolism, which is another key part of dementia progression