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Moreover, we cloned CDSs of the 12 GhGPXs in at least three independent experiments and it was found that a nucleotide sequence of 45-bp inserted between nucleotides 373 and 374 bp of the GhGPX2 CDS, leading to a 15-amino-acid (GFLGSRIKWNFTKFL) insertion between 124S (Ser) and 125 V (Val)

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To validate these findings, multiple sensitivity analyses were carried out using a variety of selection criteria and models that integrated various covariates (Table S7)

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Retatrutide's unique mechanism positions it favorably against emerging competitors and established therapies