Researchers optimizing their protocols should track: Body composition: Use DEXA scans, bioimpedance devices, or at minimum waist/hip measurements to distinguish fat loss from lean mass loss Resting heart rate: Particularly important with retatrutide due to the glucagon-mediated heart rate increase Blood pressure: Both peptides lower blood pressure, which is beneficial but can cause dizziness if the drop is too rapid Fasting blood glucose: Especially relevant for those managing pre-diabetes or type 2 diabetes Liver enzymes: For anyone with suspected or confirmed fatty liver disease Energy levels and sleep quality: Subjective but important indicators of protocol tolerance The GLP-1 progress tracking tools available through SeekPeptides help members monitor these metrics systematically rather than relying on memory or sporadic tracking
Common panels include A1C or fasting glucose, kidney and liver function, fasting lipids, and thyroid markers
Birth control considerations while on tirzepatide If you are reading this section because you want to prevent pregnancy while continuing tirzepatide treatment , here is what you need to know
Check for any particulate matter, cloudiness, crystallization, or color changes from previous doses
This is more common in women
