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This process could contribute to systemic inflammation, BBB impairment, and ROS production

This colorimetric assay is based on the GST-catalyzed reaction between reduced glutathione and GST substrate, 1-chloro-2, 4-dinitrobenzene (CDNB)

While cytosolic and blood GSH and Cys biochemical species all experience depletion, the model predicts that a single exposure to doxorubicin only results in a minimal perturbation of the antioxidant defence system

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By modulating inflammatory pathways, glutathione helps alleviate liver inflammation, reducing the risk of disease progression