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If pancreatitis is suspected, discontinue WEGOVY and initiate appropriate management

Semaglutide is a GLP-1 receptor agonist that mimics the natural incretin hormone to reduce appetite, slow gastric emptying, and improve blood sugar regulation

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Thus, the Ser/Thr kinase AMPK is activated during energy depletion, when the AMP/ATP ratio increases and triggers a large number of downstream effectors by stimulating ATP-generating catabolic pathways and inhibiting anabolic pathways in order to restore the energy balance