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Participants should always follow the dose-escalation schedule provided by their trial team and should not attempt to self-adjust their dose

Management should follow standard GORD advice in line with NICE CG184, starting with dietary and lifestyle changes such as eating smaller meals, avoiding trigger foods, and not lying down after eating

Plasma pro-C3 levels have been shown to correlate with severity of steatohepatitis and fibrosis stage in patients with MASLD 35

Important safety considerations include a boxed warning regarding thyroid C-cell tumors observed in rodents (though the relevance to humans is unknown) and contraindications for patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

If you are comparing storage rules across different formulations, our article on how to store GLP-1 medications safely for best results is another useful reference