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Resveratrol induces glutathione synthesis by activation of nuclear erythroid-related factor 2 and by decreasing oxidative stress
Inhibition of the p62-KEAP1-NRF2 antioxidant signaling pathway can significantly enhance the anticancer activity of erastin and sorafenib in liver cancer cells in vivo and in vitro [67]
Designing robust clinical trials to evaluate antioxidant therapies in HTN and DM requires addressing unique challenges, including patient heterogeneity, biomarker variability, and the dual role of OS as both cause and consequence of disease progression
CRISPR-Cas9 targeting of PI3K/AKT/mTOR growth pathway inhibitors PTEN 19 and STK11 induced resistance, while loss of pathway activators GAB2 and LAMTOR5 increased sensitivity (Fig
Huachansu has been shown to inhibit liver cancer cell growth by reducing the activity and expression of glucose-6-phosphate dehydrogenase (G6PD), thereby disrupting the pentose phosphate pathway (Wu Q
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