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Reconstituted solutions should be stored at 28C and used within 714 days, or aliquoted and frozen at -20C

These changes are associated with reduced affinity for IGF-binding proteins and a prolonged active duration in experimental models

Radiology (2022) 304(1):18592

[PMC free article: PMC7157181] [PubMed: 32219386] 165

In STEP-4 (N=803, semaglutide 2.4 mg, withdrawal design, 68 weeks), patients who discontinued semaglutide regained two-thirds of prior weight loss within 1 year