It activates G-protein coupled receptors FFAR2 and FFAR3 on L cells, triggering calcium influx and subsequent GLP-1 vesicle release
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Liraglutide (Saxenda) a GLP-1 receptor agonist licensed for weight management, with a more modest but clinically meaningful effect on body weight
The high rates of obesity and diabetes among PCOS patients receiving semaglutide and tirzepatide in this study are consistent with these metabolic features and suggest that GLP-1 RA therapy may play an expanding role in addressing the metabolic aspects of PCOS
