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Excessive loss of skeletal muscle may attenuate metabolic benefits and increase the risk of weight regain [9, 10], whereas specific reduction of visceral fat may represent a key mechanism underlying cardiovascular protection

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While exposure to long-term therapy is of potential concern, it is uncertain whether drug exposure to GLP-1 receptor agonist therapies for shorter durations is of any clinical consequence 28

Sea ice has continued to sharply decline, while permafrost has thawed across large swaths of Alaska, Canada and Siberia

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