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10.1155/2022/1375892 156 RagabT

reported for the first time that osteomalacia occurred in 4 patients who used phenytoin, primidone, and phenobarbitone for long-term antiseizure therapy, possibly because drug-mediated enzyme induction led to a significant increase in the degree of vitamin D inactivation ( The relationship between vitamin D supplementation and SF in patients with DRE is controversial

However, if you have a sensitive stomach, taking them with a light snack or a morning smoothie is also perfectly acceptable

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Yanagie H, Hisa T, Ogata A, Miyazaki A, Nonaka Y, Nishihira T, Osada I, Sairennji T, Sugiyama H, Furuya Y, Kidani Y, Takamoto S, Takahashi H, Eriguchi M (2009) Improvement of sensitivity to platinum compound with siRNA knockdown of upregulated genes in platinum complex-resistant ovarian cancer cells in vitro