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Results: Mounjaro: 20.2% average weight loss Wegovy: 13.7% average weight loss Waist circumference reduction: 18.4cm (Mounjaro) vs 13.0cm (Wegovy) Achieving 20%+ weight loss: 1 in 3 Mounjaro patients vs significantly fewer on Wegovy Thats about 47% more weight loss on average with Mounjaro

It was found that transgenic mice developed HCC, which subsided when the transgene was inhibited, which showed that Met over-expression induced tumorigenesis without HGF

In rodents, this effect likely occurs through a calcitonin-dependent pathway since GLP-1 does not appear to have a direct effect on osteoblasts and osteoclasts in vitro [56]

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