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The main symptoms are numbness and tingling of the thumb, index finger, middle finger, and the thumb side of the ring finger, as well as pain in the hand and fingers

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In addition to the well-known effects of GLP-1 and GLP-1 RA in improving insulin sensitivity and reducing body weight, at central levels, GLP-1 and GLP-1 RA might exert regulating effects on GhRH release, and on concomitant gonadotropin secretion, likely by activating the kisspeptin hypothalamic system, a key regulator of the pulsatile release of GnRH from GnRH neurons

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