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If you are on oral HRT and a GLP-1 medication, your hormone levels may be subtherapeutic due to the absorption issue we discussed

There was this realization that, while obesity is not something that is a persons fault or a value judgement about their willpower or anything else, obesity has significant health risks associated with it, and we should treat it like we do other chronic illnesses, he adds

If constipation becomes a problem despite preparation, options worth discussing with your clinician include: A gentle osmotic laxative such as polyethylene glycol (MiraLAX) used on a scheduled rather than as-needed basis during dose escalation periods

While nausea, vomiting, and diarrhea are the most commonly reported gastrointestinal adverse effects with GLP-1-based therapies (occurring in 15-40% of patients depending on the agent and dose), FDA prescribing information for several of these medications does list dyspepsia (indigestion) and, in some cases, gastroesophageal reflux disease (GERD) as reported adverse reactions