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Whilst taking the time to test for GST and/or GT tumor expression may slightly delay treatment, it will ensure that GSH-conjugates anticancer prodrugs will be administered to the patients that are more likely to respond

Secondly, the in vivo distribution and pharmacokinetics of these agents are complex, and clinical trials often encounter issues such as uneven drug retention and dose-limiting toxicities, which remain critical barriers to practical application (137, 138)

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