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For example, Fusobacterium necrophorum can induce necrotizing stomatitis through the secretion of toxins and proteolytic enzymes, resulting in fever, severe ulceration, and marked reductions in feed intake

Elevated free fatty acids (FFAs) can drive the intracellular accumulation of lipid droplets (LDs) within RPE cells, inducing oxidative stress and epithelial-mesenchymal transition (EMT)processes strongly associated with AMD progression [65, 66]

If you are experiencing consistent side effects at steady state (not just during the transition), that tells you the dose itself is probably too high for your tolerance, not that you are going through a temporary adjustment period

The problem is that glutathione levels decline with age, and they drop faster under chronic stress, heavy alcohol use, smoking, and sustained environmental toxin exposure