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Endothelial cell dysfunction DAMPs significantly increase the transcription and release of pro-inflammatory factors in endothelial cells by activating TLRs and the NF-B signaling pathways, thereby triggering chronic inflammation and vascular injury

Antioxidant Protection: Vitamin E and Vitamin C contribute to the protection of cells from oxidative stress

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FOXO4-DRI competitively disrupts this interaction, potentially restoring apoptotic signaling specifically in senescent cell populations

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