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The maximal effect (E max ) model was built up as the machine-learning model

As body weight and particularly visceral fat decrease on GLP-1 treatment, the liver produces less very low-density lipoprotein, the particle that carries triglycerides through the bloodstream

doi: 10.1038/s41531-023-00603-z 47 RahimpourS.ZhangS.-C.VitekJ

Both substances affect the central nervous system and gastrointestinal system, and their combined use may amplify certain side effects or complicate clinical management

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