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122 Although glutathione reductase and glucose-6-phosphate dehydrogenase are secondary antioxidant enzymes that help maintain a steady concentration of glutathione, NADPH is necessary for optimal functioning of the primary antioxidant enzymes

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919 The latest bioinformatics analysis identified 11 key genes associated with sarcopenia, including FOXO1, HSPB1, MDH2, CDKN1A, and DLD, which are closely related to ferroptosis in sarcopenia

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It found that in participants with overweight or obesity (body mass index (BMI) 27 kg/m 2 ), once-weekly injections of 5 mg, 10 mg or 15 mg of tirzepatide led to mean weight reductions of 15%, 19.5% and 20.9%, respectively, compared to placebo