is trizepatide a glp-1 Tirzepatide, New Era of Dual-Targeted Treatment for Diabetes and Obesity: A Mini-Review The Science Behind Tirzepatide: GLP-1

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According to the UK SmPC, no dose adjustment is required in renal impairment

[5] [6] The medication works by mimicking the action of endogenous GLP-1, enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satiety through central nervous system pathways

Daryayehsalameh, B., Nabavi, M

If GI side effects are severe at any step, hold the current dose for an extra 4 weeks before escalating