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This lipotoxicity and oxidative stress vicious cycle creates a metabolic trap, which is particularly evident in glomerular mesangial cells and proximal tubular cells, thereby driving extracellular matrix deposition and the development of renal fibrosis

Til this day, I dont get it

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Defyne and Refyne are very similar, but Defyne is firmer and that means if you place it too close to the surface, youll be able to feel it, which is not ideal