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Additionally, ARC neurones also project onto the paraventricular nucleus (PVN) of the hypothalamus where important efferent pathways regulating energy expenditure arise

Along with a significant pool of preclinical data on the effect of GLP-1RAs (including exendin-4) on PD models in experimental animals, showing a decrease in the loss of dopaminergic neurons and accumulation of -synuclein in the brain, a decrease in mitochondrial dysfunction and expression of pro-inflammatory mediators such as tumor necrosis factor (TNF)- and interleukin IL-1 [61], promising data from clinical studies on the use of GLP-1RAs in PD have been obtained [62]

10.1016/j.freeradbiomed.2013.07.036 Free Radic

But gaining weight is also a possibility if you dont stick to healthy habits

Concurrent use of renin-angiotensin-aldosterone system (RAAS) inhibitors: ACE inhibitors, ARBs, and mineralocorticoid receptor antagonists all reduce renal potassium excretion